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News and Views
Nature Medicine 14, 487 - 488 (2008)
doi:10.1038/nm0508-487
Dust mites' dirty dealings with dendritic cells
Dean Sheppard1
- Dean Sheppard is in the Department of Medicine, University of California, San Francisco, UCSF Box 2922, San Francisco, California 94143-2922, USA.
e-mail: dean.sheppard@ucsf.edu
Abstract
Allergens stimulate lymphocytes to become factories for secreted proteins that cause organ dysfunction in allergic diseases. Allergens are now shown to target dendritic cells, the cells responsible for processing and presenting antigens to T cells (pages 565–573).
The immune system has evolved to identify and kill a variety of threatening microorganisms, and distinct patterns of response have emerged to effectively nullify distinct groups of invaders. The response pattern used to defend against parasites involves the generation of T lymphocytes called T helper type 2 (TH2) cells that secrete potent cytokines required for walling off and expelling parasites.
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