Three postmortem studies examine long-term fetal transplants in subjects with advanced Parkinson's disease. The findings—such as the development of parkinsonian pathology in some transplanted neurons—underscore the limitations of this approach.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar
References
Olanow, C.W. et al. Ann. Neurol. 54, 403–414 (2003).
Mendez, I. et al. Nat. Med. published online, doi:10.1038/nm1752 (6 April 2008).
Kordower, J.H. et al. Nat. Med. published online, doi:10.1038/nm1747 (6 April 2008).
Li, J.-Y. et al. Nat. Med. published online, doi:10.1038/nm1746 (6 April 2008).
Spillantini, M.G. et al. Nature 388, 839–840 (1997).
Lang, A.E. & Obeso, J.A. Lancet Neurol. 3, 309–316 (2004).
Ahlskog, J.E. Neurology 69, 1701–1711 (2007).
Langston, J.W. Ann. Neurol. 59, 591–596 (2006).
Bloch, A. et al. Neuropathol. Appl. Neurobiol. 32, 284–295 (2006).
Freed, C.R. et al. N. Engl. J. Med. 344, 710–719 (2001).
Snyder, B.J. & Olanow, C.E. Curr. Opin. Neurol. 18, 376–385 (2005).
Braak, H. & Del Tredici, K. Neurology (in the press).
Stephens, B. et al. Neuroscience 132, 741–754 (2005).
Tepper, J.M. et al. Prog. Brain Res. 160, 3–7 (2007).
Deutch, A.Y. J. Neural Transm. Suppl. 70 67–70 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Braak, H., Del Tredici, K. Assessing fetal nerve cell grafts in Parkinson's disease. Nat Med 14, 483–485 (2008). https://doi.org/10.1038/nm1768
Issue Date:
DOI: https://doi.org/10.1038/nm1768
This article is cited by
-
The stem cell potential of glia: lessons from reactive gliosis
Nature Reviews Neuroscience (2011)
