News and Views
Nature Medicine 14, 495 - 496 (2008)
doi:10.1038/nm0508-495
Bench to bedside: BRCA: From therapeutic target to therapeutic shield
Neil P Shah1
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Neil P. Shah is in the Department of Hematology/Oncology, University of California, San Francisco, 505 Parnassus Avenue, Suite M1286, Box 1270, San Francisco, California 94143, USA.
e-mail: nshah@medicine.ucsf.edu
Abstract
Three studies examine how resistance to chemotherapy develops in cancers deficient in BRCA1 and BRCA2. The mechanism involves restoration of BRCA1 and BRCA2 activity. Shah examines the implications for the clinic, such as the potential value of continuing treatment with cisplatin and similar agents even after drug resistance develops.
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