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Nature Medicine 14, 485 - 487 (2008)
doi:10.1038/nm0508-485
-adrenergic signaling in heart failure—adapt or die
Thomas Eschenhagen1
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Thomas Eschenhagen is at the Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
e-mail: t.eschenhagen@uke.uni-hamburg.de
Abstract
About 25% of the African-American population carries a gene variant that seems to protect against heart failure. The findings may have implications for the use of 
-blockers (pages 510–517).
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RESEARCH
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failureNature Medicine Article (01 May 2008)