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Letter
Nature Medicine 14, 442-447 (1 April 2008) | doi:10.1038/nm1736;
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy
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Abstract
Muscular dystrophies comprise a diverse group of genetic disorders that lead to muscle wasting and, in many instances, premature death. Many mutations that cause muscular dystrophy compromise the support network that connects myofilament proteins within the cell to the basal lamina outside the cell, rendering the sarcolemma more permeable or leaky.
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