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Nature Medicine 14, 448-453 (1 April 2008) | doi:10.1038/nm1742;

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

Christopher A Jones , Nyall R London , Haoyu Chen , Kye Won Park , Dominique Sauvaget , Rebecca A Stockton , Joshua D Wythe , Wonhee Suh , Frederic Larrieu-Lahargue , Yoh-suke Mukouyama , Per Lindblom , Pankaj Seth , Antonio Frias , Naoyuki Nishiya , Mark H Ginsberg , Holger Gerhardt , Kang Zhang & Dean Y Li

The angiogenic sprout has been compared to the growing axon, and indeed, many proteins direct pathfinding by both structures. The Roundabout (Robo) proteins are guidance receptors with well-established functions in the nervous system; however, their role in the mammalian vasculature remains ill defined.

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