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News and Views
Nature Medicine 14, 370 - 372 (2008)
doi:10.1038/nm0408-370
Bacteria fight back against Toll-like receptors
Luke A J O'Neill1
- Luke A.J. O'Neill is in the School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland e-mail: laoneill@tcd.ie
Abstract
A strain of Escherichia coli that causes urinary tract infections seems to take hold in the body by interfering with signaling through Toll-like receptors (TLRs). The mechanism involves a secreted bacterial protein that is taken up by cells and clogs up the TLR signaling mechanism (pages 399–406).
The innate immune response to infection is a rapid and highly potent process1 that often involves TLRs. TLRs are an important family of innate sensors, recognizing diverse microbial products and launching signaling pathways that ultimately lead to the clearance of the pathogen from the host and the establishment of a memory response in anticipation of any subsequent attack1.
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