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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

Christopher A Jones, Nyall R London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A Stockton, Joshua D Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-suke Mukouyama, Per Lindblom, Pankaj Seth, Antonio Frias, Naoyuki Nishiya, Mark H Ginsberg, Holger Gerhardt, Kang Zhang & Dean Y Li

Nature Medicine 14, 448 - 453 (2008) Published online: 16 March 2008

doi:10.1038/nm1742

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Figure 1

Robo4 expression is endothelial specific and stalk-cell centric.

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Figure 2

Robo4 signaling inhibits VEGF-165–induced migration, tube formation, permeability and SFK activation.

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Figure 3

Slit2 blocks oxygen-induced retinopathy in a Robo4-dependent manner.

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Figure 4

Robo4 signaling inhibits pathologic angiogenesis.

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