Brief Communication abstract


Nature Medicine 14, 379 - 381 (2008)
Published online: 23 March 2008 | doi:10.1038/nm1732

Therapeutic cloning in individual parkinsonian mice

Viviane Tabar1,2, Mark Tomishima3,5, Georgia Panagiotakos1,5, Sayaka Wakayama4, Jayanthi Menon1, Bill Chan1, Eiji Mizutani4, George Al-Shamy1, Hiroshi Ohta4, Teruhiko Wakayama4 & Lorenz Studer1,3

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Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.

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  1. Department of Neurosurgery, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA.
  2. Department of Neurosurgery, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10065, USA.
  3. Developmental Biology Program, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA.
  4. RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Kobe 650-0047, Japan.
  5. These authors contributed equally to this work.

Correspondence to: Viviane Tabar1,2 e-mail: tabarv@mskcc.org

Correspondence to: Lorenz Studer1,3 e-mail: studerl@mskcc.org



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