News and Views
Nature Medicine 14, 370 - 372 (2008)
doi:10.1038/nm0408-370
Bacteria fight back against Toll-like receptors
Luke A J O'Neill1
- Luke A.J. O'Neill is in the School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland e-mail: laoneill@tcd.ie
Abstract
A strain of Escherichia coli that causes urinary tract infections seems to take hold in the body by interfering with signaling through Toll-like receptors (TLRs). The mechanism involves a secreted bacterial protein that is taken up by cells and clogs up the TLR signaling mechanism (pages 399–406).
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