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Nature Medicine 14, 244–245 (1 March 2008) | doi:10.1038/nm0308-244
The weakness of a big heart
Abstract
Heart failure is often accompanied by enlargement of the heart (hypertrophy), as the organ strains to perform its task despite being damaged. Cell enlargement, rather than proliferation, accounts for this hypertrophy, because cardiomyocytes are terminally differentiated.
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