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Nature Medicine 14, 247 - 249 (2008)
doi:10.1038/nm0308-247
Interleukin-22: a sheep in wolf's clothing
Arian Laurence1, John J O'Shea1 & Wendy T Watford1
- Arian Laurence, John J. O'Shea and Wendy T. Watford are in the Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. e-mail: osheajo@mail.nih.gov
Abstract
Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275–281 and 282–289).
A remarkable interplay between innate and adaptive immunity occurs in the vertebrate immune system. The innate immune system recognizes stereotypical products of pathogens, whereas the adaptive immune system recognizes limitless numbers of foreign substances by virtue of rearranging antigen receptor genes in lymphocytes.
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