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Nature Medicine 14, 246 - 247 (2008)
doi:10.1038/nm0308-246
Notch inhibition reverses kidney failure
Matthias Kretzler1 & Lisa Allred1
- Matthias Kretzler and Lisa Allred are at the University of Michigan Medical Center, Department of Internal Medicine, Division of Nephrology and Center for Computational Medicine and Biology, 1560 MSRB II, 1150 W. Medical Center Drive, Ann Arbor, Michigan 48109, USA. e-mail: kretzler@umich.edu
Abstract
Inhibition of the Notch pathway reverses damage in a mouse model of kidney disease (pages 290–298). The findings suggest that blockade of the Notch pathway through inhibition of 
-secretase activity may be an approach to combating glomerular failure.
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RESEARCH
The Notch pathway in podocytes plays a role in the development of glomerular diseaseNature Medicine Article (01 Mar 2008)
