Supplementary information : Ex vivo: glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone : Nature Medicine

From the following article

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

Robert Sackstein, Jasmeen S Merzaban, Derek W Cain, Nilesh M Dagia, Joel A Spencer, Charles P Lin & Roland Wohlgemuth

Nature Medicine 14, 181 - 187 (2008) Published online: 13 January 2008

doi:10.1038/nm1703

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Supplementary Text and Figures

Supplementary Figs. 1–6 and Supplementary Methods

Supplementary Text and Figures - Download PDF file (5MB)

Supplementary Movie 1

This video segment shows a marrow sinusoidal endothelial bed within the first minute after injection of FTVI-treated, HCELL-expressing MSCs (bright cells). Note evident rolling interactions and firm adherence of MSCs onto marrow sinusoidal endothelium.

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Supplementary Movie 2

This video segment shows a marrow sinusoidal endothelial bed withing the first minute after injection of FTVI-Sialidase MSCs. Compared to HCELL+ MSCs shown in Video 1, FTVI-Sialidase MSCs show minimal binding interactions with marrow sinusoidal endothelium.

Supplementary Movie 2 - Download Audio file (3MB)

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