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Nature Medicine 14, 118 - 119 (2008)
doi:10.1038/nm0208-118
Safer, longer-lasting regulatory T cells with 
-catenin
Jeffrey A Bluestone1 & Matthias Hebrok1
- Jeffrey A. Bluestone and Matthias Hebrok are in the University of California–San Francisco Diabetes Center and Department of Medicine, University of California–San Francisco, Health Sciences West 1114, Box 0540, 513 Parnassus Avenue, San Francisco, California 94143, USA. e-mail: jbluest@diabetes.ucsf.edu
Abstract
Expressing a stabilized form of 
-catenin extends the lifespan of regulatory T cells— one goal of therapies that take advantage of these cells (pages 162–169).
The vital role of regulatory T (Treg) cells in maintaining self-tolerance is exquisitely clear1. Defects in Treg cell development lead to systemic autoimmunity and early death in both mice and humans.
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Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsNature Medicine Article (01 Feb 2008)
