Article abstract
Nature Medicine 14, 162 - 169 (2008)
Published online: 3 February 2008 | doi:10.1038/nm1707
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells
Yi Ding1,2, Shiqian Shen1, Andreia C Lino1, Maria A Curotto de Lafaille1,3 & Juan J Lafaille1,3
Abstract
-catenin is a central molecule in the Wnt pathway. Expression of a stable form of -catenin on CD4+CD25+ regulatory T (Treg) cells resulted in a marked enhancement of survival of these cells in vitro. Furthermore, stable -catenin–expressing CD4+CD25+ Treg cells outcompeted control Treg cells in vivo, and the number of Treg cells necessary for protection against inflammatory bowel disease could be substantially reduced when stable -catenin–expressing CD4+CD25+ Treg cells were used instead of control Treg cells. Expression of stable -catenin on potentially pathogenic CD4+CD25- T cells rendered these cells anergic, and the -catenin–mediated induction of anergy occurred even in Foxp3-deficient T cells. Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, -catenin stabilization has a powerful effect on the prevention of inflammatory disease.
- Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
- Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
- Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
Correspondence to: Juan J Lafaille1,3 e-mail: lafaille@saturn.med.nyu.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Safer, longer-lasting regulatory T cells with β-cateninNature Medicine News and Views (01 Feb 2008)
RESEARCH
Hyperglycemia Enhances DNA Fragmentation After Transient Cerebral IschemiaJournal of Cerebral Blood Flow & Metabolism Original Article
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
A role for Wnt signalling in self-renewal of haematopoietic stem cellsNature Article (22 May 2003)
See all 4 matches for Research
