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Letter

Nature Medicine 14, 1370-1376 (1 December 2008) | doi:10.1038/nm.1879;

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

Shigeru Shibata , Miki Nagase , Shigetaka Yoshida , Wakako Kawarazaki , Hidetake Kurihara , Hirotoshi Tanaka , Jun Miyoshi , Yoshimi Takai & Toshiro Fujita

Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of proteinuric kidney diseases. However, little is known about the regulation of mineralocorticoid receptor–dependent transcriptional activity in renal disease.

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