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Nature Medicine 14, 1309–1310 (1 December 2008) | doi:10.1038/nm1208-1309

Brain inflammation initiates seizures

Jonathan K Kleen & Gregory L Holmes

Mechanistic hypotheses of seizure initiation frequently boil down to increased neural excitation, decreased inhibition or both. However, the conditions that lead to these activation states may be comparably important for the generation of seizures and perhaps more so for epileptogenesis.