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Nature Medicine 14, 1311 - 1313 (2008)
doi:10.1038/nm1208-1311
Saving the skin from drug-induced detachment
Brian J Nickoloff1
- Brian J. Nickoloff is at the Loyola University of Chicago Medical Center, Building 112, Room 301, 2160 South First Avenue, Maywood, Illinois 60153-5385, USA.
e-mail: bnickol@lumc.edu
Abstract
Granulysin, a powerful cytolytic protein secreted from immune cells, underlies an extreme and deadly response to common medications, in which the skin blisters and sloughs off. The findings may also have implications for bone marrow transplant recipients suffering from graft-versus-host disease (pages 1343–1350).
Just as someone spending time relaxing at the beach does not expect a tsunami to wipe away the coastline, a patient taking his or her medication does not expect to have large areas of skin fall off1. But that is exactly can happen, in rare instances, to people ingesting a range of common unrelated medications, such as various antibiotics and antiseizure agents.
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RESEARCH
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysisNature Medicine Letter (01 Dec 2008)
Evaluation of the Potential Role of Cytokines in Toxic Epidermal NecrolysisJournal of Investigative Dermatology Original Article
