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Nature Medicine 14, 1309 - 1310 (2008)
doi:10.1038/nm1208-1309
Brain inflammation initiates seizures
Jonathan K Kleen1 & Gregory L Holmes1
- Jonathan K. Kleen and Gregory L. Holmes are in the Department of Neurology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA.
e-mail: Gregory.L.Holmes@Dartmouth.edu
Abstract
Interfering with the adhesion of immune cells to the cerebral vasculature holds seizures in check, potentially opening a new realm of therapeutics (pages 1377–1383).
Mechanistic hypotheses of seizure initiation frequently boil down to increased neural excitation, decreased inhibition or both. However, the conditions that lead to these activation states may be comparably important for the generation of seizures and perhaps more so for epileptogenesis.
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