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Letter

Nature Medicine 14, 1271–1277 (1 November 2008) | doi:10.1038/nm.1880

The miR-15a|[ndash]|miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

D|[eacute]|sir|[eacute]|e Bonci , Valeria Coppola , Maria Musumeci , Antonio Addario , Raffaella Giuffrida , Lorenzo Memeo , Leonardo D'Urso , Alfredo Pagliuca , Mauro Biffoni , Catherine Labbaye , Monica Bartucci , Giovanni Muto , Cesare Peschle & Ruggero De Maria

MicroRNAs (miRNAs) are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs. miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2.