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Is it my grandparents' fault?

Results from two independent groups of researchers have revolutionized our thinking about the potential long-term consequences of exposure to common foreign chemicals, or xenobiotics. The studies indicate that exposure to such chemicals during key windows of gestation can affect not only the children exposed in utero but also their children and perhaps even their grandchildren.

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References

  1. Susiarjo, M. et al. PLoS Genet. 3, e5 (2007).

    Google Scholar 

  2. Anway, M.D. et al. Science 308, 1466–1469 (2005).

    Google Scholar 

  3. vom Saal, F.S. et al. Reprod. Toxicol. 24, 131–138 (2007).

    Google Scholar 

  4. Environment Canada. Existing Substances Evaluation http://www.ec.gc.ca/substances/ese/eng/challenge/batch2/batch2_80-05-7.cfm (2007).

  5. Lang, I.A. et al. J. Am. Med. Assoc. 300, 1303–1310 (2008).

    Google Scholar 

  6. Pacchierotti, F. et al. Mutat. Res. 651, 64–70 (2008).

    Google Scholar 

  7. Cummings, A.M. Crit. Rev. Toxicol. 27, 367–379 (1997).

    Google Scholar 

  8. Bayley, M. et al. Biol. Reprod. 69, 1951–1956 (2003).

    Google Scholar 

  9. Anway, M.D. et al. J. Androl. 27, 868–879 (2006).

    Google Scholar 

  10. Skinner, M.K. & Anway, M.D. Crit. Rev. Oncog. 13, 75–82 (2007).

    Google Scholar 

  11. Nilsson, E.E. et al. Reproduction 135, 713–721 (2008).

    Google Scholar 

  12. Crews, D. et al. Proc. Natl. Acad. Sci. USA 104, 5942–5946 (2007).

    Google Scholar 

  13. Schneider, S. et al. Reprod. Toxicol. 25, 352–360 (2008).

    Google Scholar 

  14. Gray, L.E., Jr & Furr, J. Biol. Reprod. 78 Suppl 1, 246 (2008).

    Google Scholar 

Download references

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Robaire, B. Is it my grandparents' fault?. Nat Med 14, 1186–1187 (2008). https://doi.org/10.1038/nm1108-1186

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