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News and Views
Nature Medicine 14, 1150 - 1151 (2008)
doi:10.1038/nm1108-1150
HLA class I: friend and foe of multiple sclerosis
Roland Martin1
- Roland Martin is at the Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Center for Molecular Neurobiology Hamburg, University Medical Center Eppendorf, Falkenried 94, 20251 Hamburg, Germany.
e-mail: roland.martin@zmnh.uni-hamburg.de
Abstract
Findings in a mouse model of multiple sclerosis highlight the contribution of CD8+ T cells, previously largely ignored in this disease. The work also helps answer why certain variants of the human leukocyte antigen (HLA) complex are protective, while others increase risk for disease (pages 1227–1235).
Certain alleles of the human leukocyte antigen (HLA) type II complex are associated with increased risk of developing certain autoimmune diseases such as rheumatoid arthritis, type I diabetes and multiple sclerosis. A single haplotype, HLADR15—encoding the HLA-DR alleles DRB1*1501 and DRB5*0101—confers most of the genetic risk for multiple sclerosis.
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