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5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

Hendrik Poeck, Robert Besch, Cornelius Maihoefer, Marcel Renn, Damia Tormo, Svetlana Shulga Morskaya, Susanne Kirschnek, Evelyn Gaffal, Jennifer Landsberg, Johannes Hellmuth, Andreas Schmidt, David Anz, Michael Bscheider, Tobias Schwerd, Carola Berking, Carole Bourquin, Ulrich Kalinke, Elisabeth Kremmer, Hiroki Kato, Shizuo Akira, Rachel Meyers, Georg Häcker, Michael Neuenhahn, Dirk Busch, Jürgen Ruland, Simon Rothenfusser, Marco Prinz, Veit Hornung, Stefan Endres, Thomas Tüting & Gunther Hartmann

Nature Medicine 14, 1256 - 1263 (2008) Published online: 2 November 2008

doi:10.1038/nm.1887

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

3p-2.2 siRNA potently silences Bcl2 expression and reduces metastatic growth of B16 melanoma cells in the lungs.

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Figure 2

Activation of type I IFNs and NK cells are necessary for the antitumor activity of Bcl2-specific 3p-siRNA in vivo.

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Figure 3

Bcl-2-specific 3p-siRNA induces cell type specific innate immune responses and apoptosis in vitro.

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Figure 4

Bcl2-specific gene silencing and activation of the innate immune system synergistically promote tumor cell apoptosis in vivo.

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Figure 5

Bcl2-specific gene silencing contributes to Bcl2-specific 3p-siRNA–induced inhibition of tumor growth and apoptosis.

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Figure 6

Bcl2-specific 3p-siRNA is effective in other models of tumorigenesis and in human melanoma cells.

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