Focus on Reproductive Biology

1. Takiko Daikoko and Sudhansu K. Dey are in the Division of Reproductive Sciences, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.
   e-mail: sk.dey@cchmc.org

Abstract

A small number of women (approximately 1%) suffer from premature ovarian failure in which their ovarian follicle reserve is exhausted before age 40. Recent studies in mice show that the absence of a tumor suppressor gene, PTEN, in oocytes prematurely induces global follicular activation, depleting the follicle reserve in a manner similar to premature ovarian failure.

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