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News and Views
Nature Medicine 14, 1015 - 1016 (2008)
doi:10.1038/nm1008-1015
Getting to the core of atherosclerosis
Nancy R Webb1
- Nancy R. Webb is in the University of Kentucky Department of Medicine, Cardiovascular Research Center, 535 Wethington Building, 900 South Limestone, Lexington, Kentucky 40536-0200, USA.
e-mail: nrwebb1@uky.edu
Abstract
For years, researchers have debated whether the enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2), produced by inflammatory cells, is a 'good guy' or 'bad guy' in atherosclerosis. Work in pigs provides strong support for the view that Lp-PLA2 promotes the formation of atherosclerotic lesions and dangerous, unstable atherosclerotic plaques (pages 1059–1066).
Atherosclerosis is a progressive disease of the arteries and is the primary cause of heart attacks and strokes. The atherosclerotic process is initiated when low-density lipoprotein cholesterol (LDL; the 'bad' cholesterol) accumulates in the artery1, 2.
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