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Correspondence
Nature Medicine 14, 1008 - 1009 (2008)
doi:10.1038/nm1008-1008
SNO-hemoglobin and hypoxic vasodilation
Jonathan S Stamler1,2, David J Singel3 & Claude A Piantadosi1
- Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
e-mail: staml001@mc.duke.edu - Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
- Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, USA.
In a recent Letter in Nature Medicine, Isbell et al.1 state that S-nitrosohemoglobin (SNO-Hb) is not essential for hypoxic vasodilation on the basis of observations in mice in which both the 
- and 
-chains of hemoglobin had been replaced with the human versions, with or without mutation of the Cys93 residue of the -chain (Cys93) to alanine. More specifically, the authors indicate that Cys93 mutation "resulted in no deficits in systemic or pulmonary hemodynamics.
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