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Nature Medicine 14, 17 - 19 (2008)
doi:10.1038/nm0108-17
The movers and shakers of deep brain stimulation
- Wael Asaad and Emad Eskandar are in the Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. e-mail: eeskandar@partners.org
Abstract
Deep brain stimulation is increasingly used in the treatment of Parkinson's disease, essential tremor and other disorders, yet its mechanism of action remains unknown. New findings suggest that at least some of its action involves the release of adenosine, dampening tremors (pages 75–80).
Deep brain stimulation (DBS) has been used successfully in the treatment of neurologic illnesses such as Parkinson's disease, tremor and dystonia, and it is currently being explored as a treatment for major depression and obsessive-compulsive disorder. Yet, empirical efficacy aside, little is known of the mechanisms by which the electrical stimulation of deep brain structures alleviates these conditions.
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RESEARCH
Adenosine is crucial for deep brain stimulation?mediated attenuation of tremorNature Medicine Letter (01 Jan 2008)
