Brief Communication abstract
Nature Medicine 14, 25 - 27 (2008)
Published online: 6 December 2007 | doi:10.1038/nm1698
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
Mansun Law1, Toshiaki Maruyama1,9, Jamie Lewis4, Erick Giang1, Alexander W Tarr5, Zania Stamataki6, Pablo Gastaminza3, Francis V Chisari3, Ian M Jones7, Robert I Fox8, Jonathan K Ball5, Jane A McKeating6, Norman M Kneteman4 & Dennis R Burton1,2
A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver–chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.
- Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
- Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
- Departments of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
- Department of Surgery, University of Alberta, 2-75 Heritage Medical Research Building, 114 Street and 87 Avenue, Edmonton, Alberta T6G 2S2, Canada.
- Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, the University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
- Division of Immunity and Infection, Institute of Biomedical Research, Medical School, University of Birmingham, Birmingham B15 2TT, UK.
- School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AH, UK.
- Rheumatology Clinic, Scripps Memorial Hospital, 9850 Genesee Avenue #910, La Jolla, California 92037, USA.
- Present address: Calmune Corporation, Suite 130, 9393 Towne Center Drive, San Diego, California 92121, USA.
Correspondence to: Norman M Kneteman4 e-mail: norm.kneteman@capitalhealth.ca
Correspondence to: Dennis R Burton1,2 e-mail: burton@scripps.edu
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