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Nature Medicine 13, 1015–1016 (1 September 2007) | doi:10.1038/nm0907-1015
The clot thickens|[mdash]|oxidized lipids and thrombosis
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Abstract
One of the major obstacles to increased longevity is atherosclerosis, an inflammatory disorder that leads to fibrous, fatty lesions in the arterial wall. Advanced atherosclerotic lesions (plaques) are prone to rupture, exposing thrombogenic elements that promote excessive platelet and fibrin accumulation, leading to the formation of arterial thrombi (clots).
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