Uninformed consent? - p999

doi:10.1038/nm0907-999

Abstract - | Full Text - Uninformed consent? | PDF (89 KB) - Uninformed consent?

Alternative therapies finding acceptance in mainstream medicine - p1001

Meredith Wadman

doi:10.1038/nm0907-1001

Abstract - | Full Text - Alternative therapies finding acceptance in mainstream medicine | PDF (223 KB) - Alternative therapies finding acceptance in mainstream medicine

Allegations of bias cloud conflicting reports on bisphenol A's effects - p1002

Cassandra Willyard

doi:10.1038/nm0907-1002a

Abstract - | Full Text - Allegations of bias cloud conflicting reports on bisphenol A's effects | PDF (116 KB) - Allegations of bias cloud conflicting reports on bisphenol A's effects

DDT's ability to repel mosquitoes trumps resistance, scientists say - pp1002 - 1003

Alisa Opar

doi:10.1038/nm0907-1002b

Abstract - | Full Text - DDT's ability to repel mosquitoes trumps resistance, scientists say | PDF (231 KB) - DDT's ability to repel mosquitoes trumps resistance, scientists say

Bone marrow transplant paper revives contentious debate on fertility - p1003

Kendall Powell

doi:10.1038/nm0907-1003

Abstract - | Full Text - Bone marrow transplant paper revives contentious debate on fertility | PDF (167 KB) - Bone marrow transplant paper revives contentious debate on fertility

Lack of training in biodefense research leading to dangerous leaks - p1004

Cassandra Willyard

doi:10.1038/nm0907-1004

Abstract - | Full Text - Lack of training in biodefense research leading to dangerous leaks | PDF (244 KB) - Lack of training in biodefense research leading to dangerous leaks

Arsenic patent keeps drug for rare cancer out of reach of many - p1005

David Cyranoski

doi:10.1038/nm0907-1005

Abstract - | Full Text - Arsenic patent keeps drug for rare cancer out of reach of many | PDF (188 KB) - Arsenic patent keeps drug for rare cancer out of reach of many

News in brief - pp1006 - 1007

doi:10.1038/nm0907-1006

Abstract - | Full Text - News in brief | PDF (721 KB) - News in brief

Therapy on trial - pp1008 - 1009

Virginia Hughes

doi:10.1038/nm0907-1008

Abstract - | Full Text - Therapy on trial | PDF (346 KB) - Therapy on trial

Straight talk from... James Love - p1010

Apoorva Mandavilli

doi:10.1038/nm0907-1010

Abstract - | Full Text - Straight talk from... James Love | PDF (118 KB) - Straight talk from... James Love

State of clinical research ethics in Pakistan - p1011

Muhammad N Ghayur, Ayesha Ghayur & Luke J Janssen

doi:10.1038/nm0907-1011

Full Text - State of clinical research ethics in Pakistan | PDF (64 KB) - State of clinical research ethics in Pakistan

Angels and demons; heroes and villains - p1013

Michael J Zigmond reviews The Cult of Pharmacology: How America Became the World's Most Troubled Drug Culture by Richard J DeGrandpre

doi:10.1038/nm0907-1013

Full Text - Angels and demons; heroes and villains | PDF (84 KB) - Angels and demons; heroes and villains

The clot thickens—oxidized lipids and thrombosis - pp1015 - 1016

Shaun P Jackson & Anna C Calkin

doi:10.1038/nm0907-1015

Abstract - | Full Text - The clot thickens—oxidized lipids and thrombosis | PDF (497 KB) - The clot thickens—oxidized lipids and thrombosis

See also: Article by Podrez et al.

Muscle growth learns new tricks from an old dog - pp1016 - 1018

Gustavo A Nader

doi:10.1038/nm0907-1016

Abstract - | Full Text - Muscle growth learns new tricks from an old dog | PDF (458 KB) - Muscle growth learns new tricks from an old dog

Schizophrenia drug says goodbye to dopamine - pp1018 - 1019

Daniel R Weinberger

doi:10.1038/nm0907-1018

Abstract - | Full Text - Schizophrenia drug says goodbye to dopamine | PDF (175 KB) - Schizophrenia drug says goodbye to dopamine

See also: Letter by Patil et al.

Diseased red blood cells topple iron balance - pp1020 - 1021

Stella T Chou & Mitchell J Weiss

doi:10.1038/nm0907-1020

Abstract - | Full Text - Diseased red blood cells topple iron balance | PDF (784 KB) - Diseased red blood cells topple iron balance

See also: Letter by Tanno et al.

A skeleton key to metabolism - pp1021 - 1023

T John Martin

doi:10.1038/nm0907-1021

Abstract - | Full Text - A skeleton key to metabolism | PDF (228 KB) - A skeleton key to metabolism

Malaria's journey through the lymph node - pp1023 - 1024

Michael F Good & Denise L Doolan

doi:10.1038/nm0907-1015

Abstract - | Full Text - Malaria's journey through the lymph node | PDF (288 KB) - Malaria's journey through the lymph node

See also: Article by Chakravarty et al.

Sparking consciousness - p1025

Katherine Stevens

doi:10.1038/nm0907-1025

Full Text - Sparking consciousness | PDF (187 KB) - Sparking consciousness

Research Highlights - pp1026 - 1027

doi:10.1038/nm0907-1026

Full Text - Research Highlights | PDF (160 KB) - Research Highlights

Clearance of amyloid- by circulating lipoprotein receptors - pp1029 - 1031

Abhay Sagare, Rashid Deane, Robert D Bell, Bradley Johnson, Katie Hamm, Ronan Pendu, Andrew Marky, Peter J Lenting, Zhenhua Wu, Troy Zarcone, Alison Goate, Kevin Mayo, David Perlmutter, Mireia Coma, Zhihui Zhong & Berislav V Zlokovic

doi:10.1038/nm1635

Abstract - | Full Text - Clearance of amyloid- by circulating lipoprotein receptors | PDF (180 KB) - Clearance of amyloid- by circulating lipoprotein receptors | Supplementary information

Broad HIV-1 neutralization mediated by CD4-binding site antibodies - pp1032 - 1034

Yuxing Li, Stephen A Migueles, Brent Welcher, Krisha Svehla, Adhuna Phogat, Mark K Louder, Xueling Wu, George M Shaw, Mark Connors, Richard T Wyatt & John R Mascola

doi:10.1038/nm1624

Abstract - | Full Text - Broad HIV-1 neutralization mediated by CD4-binding site antibodies | PDF (234 KB) - Broad HIV-1 neutralization mediated by CD4-binding site antibodies | Supplementary information

CD8⁺ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes - pp1035 - 1041

Sumana Chakravarty, Ian A Cockburn, Salih Kuk, Michael G Overstreet, John B Sacci & Fidel Zavala

doi:10.1038/nm1628

Abstract - | Full Text - CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes | PDF (289 KB) - CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes | Supplementary information

See also: News and Views by Good & Doolan

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock - pp1042 - 1049

Thomas Vogl, Klaus Tenbrock, Stephan Ludwig, Nadja Leukert, Christina Ehrhardt, Marieke A D van Zoelen, Wolfgang Nacken, Dirk Foell, Tom van der Poll, Clemens Sorg & Johannes Roth

doi:10.1038/nm1638

Abstract - | Full Text - Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock | PDF (339 KB) - Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock | Supplementary information

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy - pp1050 - 1059

Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Michel Obeid, Carla Ortiz, Alfredo Criollo, Grégoire Mignot, M Chiara Maiuri, Evelyn Ullrich, Patrick Saulnier, Huan Yang, Sebastian Amigorena, Bernard Ryffel, Franck J Barrat, Paul Saftig, Francis Levi, Rosette Lidereau, Catherine Nogues, Jean-Paul Mira, Agnès Chompret, Virginie Joulin, Françoise Clavel-Chapelon, Jean Bourhis, Fabrice André, Suzette Delaloge, Thomas Tursz, Guido Kroemer & Laurence Zitvogel

doi:10.1038/nm1622

Abstract - | Full Text - Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy | PDF (488 KB) - Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy | Supplementary information

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers - pp1060 - 1069

Liyong Zhang, Michael S Anglesio, Maureen O'Sullivan, Fan Zhang, Ge Yang, Renu Sarao, Mai P Nghiem, Shane Cronin, Hiromitsu Hara, Nataliya Melnyk, Liheng Li, Teiji Wada, Peter P Liu, Jason Farrar, Robert J Arceci, Poul H Sorensen & Josef M Penninger

doi:10.1038/nm1621

Abstract - | Full Text - The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers | PDF (1,032 KB) - The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers | Supplementary information

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL - pp1070 - 1077

Klaus W Wagner, Elizabeth A Punnoose, Thomas Januario, David A Lawrence, Robert M Pitti, Kate Lancaster, Dori Lee, Melissa von Goetz, Sharon Fong Yee, Klara Totpal, Ling Huw, Viswanatham Katta, Guy Cavet, Sarah G Hymowitz, Lukas Amler & Avi Ashkenazi

doi:10.1038/nm1627

Abstract - | Full Text - Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL | PDF (567 KB) - Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL | Supplementary information

Lack of Fas antagonism by Met in human fatty liver disease - pp1078 - 1085

Chunbin Zou, Jihong Ma, Xue Wang, Lida Guo, Zhenqi Zhu, John Stoops, Amanda E Eaker, Carla J Johnson, Stephen Strom, George K Michalopoulos, Marie C DeFrances & Reza Zarnegar

doi:10.1038/nm1625

Abstract - | Full Text - Lack of Fas antagonism by Met in human fatty liver disease | PDF (704 KB) - Lack of Fas antagonism by Met in human fatty liver disease | Supplementary information

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype - pp1086 - 1095

Eugene A Podrez, Tatiana V Byzova, Maria Febbraio, Robert G Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J Finton, Brian R Curtis, Juhua Chen, Renliang Zhang, Roy L Silverstein & Stanley L Hazen

doi:10.1038/nm1626

Abstract - | Full Text - Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype | PDF (339 KB) - Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype | Supplementary information

See also: News and Views by Jackson & Calkin

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin - pp1096 - 1101

Toshihiko Tanno, Natarajan V Bhanu, Patricia A Oneal, Sung-Ho Goh, Pamela Staker, Y Terry Lee, John W Moroney, Christopher H Reed, Naomi LC Luban, Rui-Hong Wang, Thomas E Eling, Richard Childs, Tomas Ganz, Susan F Leitman, Suthat Fucharoen & Jeffery L Miller

doi:10.1038/nm1629

Abstract - | Full Text - High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin | PDF (263 KB) - High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin | Supplementary information

See also: News and Views by Chou & Weiss

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial - pp1102 - 1107

Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova, Sergey N Mosolov, Nikolai G Neznanov, Alexander M Reznik, Anatoly B Smulevich, Vladimir A Tochilov, Bryan G Johnson, James A Monn & Darryle D Schoepp

doi:10.1038/nm1632

Abstract - | Full Text - Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial | PDF (231 KB) - Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial | Supplementary information

See also: News and Views by Weinberger

A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist - pp1108 - 1113

Ian R Wilkinson, Eric Ferrandis, Peter J Artymiuk, Marc Teillot, Chantal Soulard, Caroline Touvay, Sarbendra L Pradhananga, Sue Justice, Zida Wu, Kin C Leung, Christian J Strasburger, Jon R Sayers & Richard J Ross

doi:10.1038/nm1610

Abstract - | Full Text - A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist | PDF (326 KB) - A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist

Molecular imaging of Akt kinase activity - pp1114 - 1119

Limin Zhang, Kuei C Lee, Mahaveer S Bhojani, Amjad P Khan, Alla Shilman, Eric C Holland, Brian D Ross & Alnawaz Rehemtulla

doi:10.1038/nm1608

Abstract - | Full Text - Molecular imaging of Akt kinase activity | PDF (342 KB) - Molecular imaging of Akt kinase activity

Corrigenda: Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome - p1120

Lydia E Kuo, Joanna B Kitlinska, Jason U Tilan, Lijun Li, Stephen B Baker, Michael D Johnson, Edward W Lee, Mary Susan Burnett, Stanley T Fricke, Richard Kvetnansky, Herbert Herzog & Zofia Zukowska

doi:10.1038/nm0907-1120

Full Text - Corrigenda: Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome | PDF (43 KB) - Corrigenda: Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome