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News and Views
Nature Medicine 13, 1023 - 1024 (2007)
doi:10.1038/nm0907-1015
Malaria's journey through the lymph node
Michael F Good1 & Denise L Doolan1
- Michael F. Good and Denise L. Doolan are in the Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, 300 Herston Road, PO Royal Brisbane Hospital, Brisbane QLD 4029, Australia. e-mail: Michael.Good@qimr.edu.au
e-mail: Denise.Doolan@qimr.edu.au
Abstract
T cells attack Plasmodium-infected hepatocytes when fighting malaria, and it was thought that T cells first encountered Plasmodium antigens in the liver. Instead, immediately after infection, small numbers of parasites drain to skin lymph nodes where they can prime T cells to mount a protective immune response (pages 1035–1041).
The causative agent of malaria, the Plasmodium sp. parasite, was shown to be transmitted by mosquitoes over 100 years ago.
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