Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 1020 - 1021 (2007)
doi:10.1038/nm0907-1020
Diseased red blood cells topple iron balance
Stella T Chou1 & Mitchell J Weiss1
- Stella T. Chou and Mitchell J. Weiss are in the Division of Hematology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, Pennsylvania 19104, USA. e-mail: weissmi@email.chop.edu
Abstract
In the inherited anemia 
-thalassemia, diseased red blood cell precursors release a blood-borne signal that promotes excessive intestinal iron absorption, predisposing affected individuals to multiorgan damage (pages 1096–1101).
Healthy bodies are fastidious about iron. This essential nutrient is required for the function of many endogenous proteins, most predominantly the red blood cell (RBC) oxygen transporter hemoglobin.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidinNature Medicine Letter (01 Sep 2007)
Effect of aluminum mobilization on hemoglobin during the first six months after transplantationKidney International Original Article
See all 4 matches for Research