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Nature Medicine 13, 1020 - 1021 (2007)
doi:10.1038/nm0907-1020

Diseased red blood cells topple iron balance

Stella T Chou1 & Mitchell J Weiss1

  1. Stella T. Chou and Mitchell J. Weiss are in the Division of Hematology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, Pennsylvania 19104, USA. e-mail: weissmi@email.chop.edu


In the inherited anemia beta-thalassemia, diseased red blood cell precursors release a blood-borne signal that promotes excessive intestinal iron absorption, predisposing affected individuals to multiorgan damage (pages 1096–1101).

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