Table of contents


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Editorial

Why review? p887

doi:10.1038/nm0807-887


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News

Executed Chinese drug czar corrupted by system, observers say p889

David Cyranoski

doi:10.1038/nm0807-889


Africa's HIV transmission laws based on questionable science p890

Cassandra Willyard

doi:10.1038/nm0807-890a


UK set to reverse stance on research with chimeras pp890 - 891

Michael Hopkin

doi:10.1038/nm0807-890b


Dearth of data deters new institute to evaluate global health aid p891

Cassandra Willyard

doi:10.1038/nm0807-891


Nominee for US top doc grilled on political pressure p892

Meredith Wadman

doi:10.1038/nm0807-892


Straight talk from... Ashok Alexander p893

Paroma Basu

doi:10.1038/nm0807-893


News in brief pp894 - 895

doi:10.1038/nm0807-894


Mercury rising pp896 - 897

Virginia Hughes

doi:10.1038/nm0807-896


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Book Review

Must maternity medicine be reborn? p899

Errol R Norwitz reviews Pushed: The Painful Truth about Childbirth and Modern Maternity Care by Jennifer Block

doi:10.1038/nm0807-899


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News and Views

Cardiac aid to the injured but not the elderly? pp901 - 902

Charles E Murry

doi:10.1038/nm0807-901

See also: Letter by Hsieh et al.


The curiosity of IL-15 pp903 - 904

Peter A Ward

doi:10.1038/nm0807-903

See also: Article by Orinska et al.


Rosacea: skin innate immunity gone awry? pp904 - 906

Charles L Bevins & Fu-Tong Liu

doi:10.1038/nm0807-904

See also: Letter by Yamasaki et al.


Pathogens cooperate in lymphomagenesis pp906 - 907

David A Thorley-Lawson & Karen A Duca

doi:10.1038/nm0807-906


Peroxiredoxin-2 links Cdk5 to neurodegeneration pp907 - 909

Serge Przedborski

doi:10.1038/nm0807-907


Streptococcus pyogenes under pressure pp909 - 910

Claire Turner & Shiranee Sriskandan

doi:10.1038/nm0807-909

See also: Letter by Walker et al.


Research Highlights p911

doi:10.1038/nm0807-911


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Articles

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells pp913 - 919

Marco Idzko, Hamida Hammad, Menno van Nimwegen, Mirjam Kool, Monique A M Willart, Femke Muskens, Henk C Hoogsteden, Werner Luttmann, Davide Ferrari, Francesco Di Virgilio, J Christian Virchow, Jr & Bart N Lambrecht

doi:10.1038/nm1617


E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury pp920 - 926

Kurt Bachmaier, Sophie Toya, Xiaopei Gao, Thomas Triantafillou, Sean Garrean, Gye Young Park, Randall S Frey, Stephen Vogel, Richard Minshall, John W Christman, Chinnaswamy Tiruppathi & Asrar B Malik

doi:10.1038/nm1607


IL-15 constrains mast cell–dependent antibacterial defenses by suppressing chymase activities pp927 - 934

Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel, Ernst Brandt, Ralf Paus & Silvia Bulfone-Paus

doi:10.1038/nm1615

See also: News and Views by Ward


Type II monocytes modulate T cell–mediated central nervous system autoimmune disease pp935 - 943

Martin S Weber, Thomas Prod'homme, Sawsan Youssef, Shannon E Dunn, Cynthia D Rundle, Linda Lee, Juan C Patarroyo, Olaf Stüve, Raymond A Sobel, Lawrence Steinman & Scott S Zamvil

doi:10.1038/nm1620


Essential role of stromally induced hedgehog signaling in B-cell malignancies pp944 - 951

Christine Dierks, Jovana Grbic, Katja Zirlik, Ronak Beigi, Nathan P Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F Kelleher, Peter Schultz & Markus Warmuth

doi:10.1038/nm1614


Endothelial-to-mesenchymal transition contributes to cardiac fibrosis pp952 - 961

Elisabeth M Zeisberg, Oleg Tarnavski, Michael Zeisberg, Adam L Dorfman, Julie R McMullen, Erika Gustafsson, Anil Chandraker, Xueli Yuan, William T Pu, Anita B Roberts, Eric G Neilson, Mohamed H Sayegh, Seigo Izumo & Raghu Kalluri

doi:10.1038/nm1613


Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair pp962 - 969

Bernhard Kühn, Federica del Monte, Roger J Hajjar, Yuh-Shin Chang, Djamel Lebeche, Shima Arab & Mark T Keating

doi:10.1038/nm1619


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Letters

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury pp970 - 974

Patrick C H Hsieh, Vincent F M Segers, Michael E Davis, Catherine MacGillivray, Joseph Gannon, Jeffery D Molkentin, Jeffrey Robbins & Richard T Lee

doi:10.1038/nm1618

See also: News and Views by Murry


Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea pp975 - 980

Kenshi Yamasaki, Anna Di Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Alvin Coda, Robert A Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B Morhenn & Richard L Gallo

doi:10.1038/nm1616

See also: News and Views by Bevins & Liu


DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection pp981 - 985

Mark J Walker, Andrew Hollands, Martina L Sanderson-Smith, Jason N Cole, Joshua K Kirk, Anna Henningham, Jason D McArthur, Katrin Dinkla, Ramy K Aziz, Rita G Kansal, Amelia J Simpson, John T Buchanan, Gursharan S Chhatwal, Malak Kotb & Victor Nizet

doi:10.1038/nm1612

See also: News and Views by Turner & Sriskandan


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Technical Reports

Magnetic resonance–guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells pp986 - 991

Brad P Barnett, Aravind Arepally, Parag V Karmarkar, Di Qian, Wesley D Gilson, Piotr Walczak, Valerie Howland, Leo Lawler, Cal Lauzon, Matthias Stuber, Dara L Kraitchman & Jeff W M Bulte

doi:10.1038/nm1581


A spatially and temporally restricted mouse model of soft tissue sarcoma pp992 - 997

David G Kirsch, Daniela M Dinulescu, John B Miller, Jan Grimm, Philip M Santiago, Nathan P Young, G Petur Nielsen, Bradley J Quade, Christopher J Chaber, Christian P Schultz, Osamu Takeuchi, Roderick T Bronson, Denise Crowley, Stanley J Korsmeyer, Sam S Yoon, Francis J Hornicek, Ralph Weissleder & Tyler Jacks

doi:10.1038/nm1602


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