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News and Views
Nature Medicine 13, 907 - 909 (2007)
doi:10.1038/nm0807-907
Peroxiredoxin-2 links Cdk5 to neurodegeneration
Serge Przedborski1
- Serge Przedborski is in the Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032, USA. e-mail: sp30@columbia.edu
Abstract
Cyclin-dependent kinase 5, a serine/threonine kinase, contributes to neurodegeneration in Parkinson's disease. This kinase is now shown to phosphorylate peroxiredoxin-2, inactivating it, and thereby sensitizing neurons to the deleterious effects of parkinsonian toxins.
Parkinson's disease is one of the most prevalent neurodegenerative diseases, affecting roughly a million individuals in the US alone1. Like Alzheimer's disease and amyotrophic lateral sclerosis (ALS), Parkinson's disease is progressive, arises sporadically, is idiopathic and has no cure1.
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