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Nature Medicine 13, 909 - 910 (2007)
doi:10.1038/nm0807-909
Streptococcus pyogenes under pressure
Claire Turner1 & Shiranee Sriskandan1
- Claire Turner and Shiranee Sriskandan are in the Department of Infectious Diseases & Immunity, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. e-mail: s.sriskandan@imperial.ac.uk
Abstract
Contemporary M1 strains of Streptococcus pyogenes have acquired a DNase gene that improves the virulence of the bacterium, but its expression is repressed by the CovRS regulatory system. Walker et al. report that the bacteria are under selective pressure to mutate the covRS locus to maintain DNase expression for invasive infection (pages 982–986).
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RESEARCH
DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infectionNature Medicine Letter (01 Aug 2007)
Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosisNature Medicine Article (01 Dec 2001)
EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgGThe EMBO Journal Article (15 Jun 2001)
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