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Nature Medicine 13, 904 - 906 (2007)
doi:10.1038/nm0807-904
Rosacea: skin innate immunity gone awry?
Charles L Bevins1 & Fu-Tong Liu2
- Charles L. Bevins is in the Departments of Microbiology and Immunology, School of Medicine, and Graduate Group in Immunology, University of California, Davis, California 95616, USA. e-mail: clbevins@ucdavis.edu
- Fu-Tong Liu is in the Department of Dermatology, School of Medicine, and Graduate Group in Immunology, University of California, Sacramento, California 95817, USA. e-mail: fliu@ucdavis.edu
Abstract
Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975–981).
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