A power surge before a short circuit - p761

doi:10.1038/nm0707-761

Abstract - A power surge before a short circuit | Full Text - A power surge before a short circuit | PDF (98 KB) - A power surge before a short circuit

Pfizer lawsuit spotlights ethics of developing world clinical trials - p763

Cassandra Willyard

doi:10.1038/nm0707-763

Abstract - Pfizer lawsuit spotlights ethics of developing world clinical trials | Full Text - Pfizer lawsuit spotlights ethics of developing world clinical trials | PDF (119 KB) - Pfizer lawsuit spotlights ethics of developing world clinical trials

Scientists stir the pot for right to grow marijuana - p764

Arran Frood

doi:10.1038/nm0707-764a

Abstract - Scientists stir the pot for right to grow marijuana | Full Text - Scientists stir the pot for right to grow marijuana | PDF (99 KB) - Scientists stir the pot for right to grow marijuana

New schemes aim to boost minority participation in research - pp764 - 765

Alisa Opar

doi:10.1038/nm0707-764b

Abstract - New schemes aim to boost minority participation in research | Full Text - New schemes aim to boost minority participation in research | PDF (183 KB) - New schemes aim to boost minority participation in research

Ethicists balk at new emergency trials that skip informed consent - p765

Andrea Anderson

doi:10.1038/nm0707-765

Abstract - Ethicists balk at new emergency trials that skip informed consent | Full Text - Ethicists balk at new emergency trials that skip informed consent | PDF (137 KB) - Ethicists balk at new emergency trials that skip informed consent

Oz stem cell clinic turns to diseased embryos - p766

Simon Grose

doi:10.1038/nm0707-766a

Abstract - Oz stem cell clinic turns to diseased embryos | Full Text - Oz stem cell clinic turns to diseased embryos | PDF (91 KB) - Oz stem cell clinic turns to diseased embryos

Teams trail genes for human 'stemness' - p766

David Cyranoski

doi:10.1038/nm0707-766b

Abstract - Teams trail genes for human 'stemness' | Full Text - Teams trail genes for human 'stemness' | PDF (91 KB) - Teams trail genes for human 'stemness'

Straight talk from... Bruce Psaty - p767

Emma Marris

doi:10.1038/nm0707-767

Abstract - Straight talk from... : Bruce Psaty | Full Text - Straight talk from... Bruce Psaty | PDF (123 KB) - Straight talk from... Bruce Psaty

News in brief - pp768 - 769

doi:10.1038/nm0707-768

Full Text - News in brief | PDF (304 KB) - News in brief

Second chance - pp770 - 771

Erika Check

doi:10.1038/nm0707-770

Abstract - Second chance | Full Text - Second chance | PDF (144 KB) - Second chance

Reply to 'In vivo imaging of islet transplantation' - p773

Frantisek Saudek, Peter Girman, Jan Kriz, Daniel Jirak & Milan Hajek

doi:10.1038/nm0707-773a

Full Text - Reply to 'In vivo imaging of islet transplantation' | PDF (88 KB) - Reply to 'In vivo imaging of islet transplantation'

Reply to 'In vivo imaging of islet transplantation' - p773

Anna Moore, Zdravka Medarova, Natalia V Evgenov, Guangping Dai & Susan Bonner-Weir

doi:10.1038/nm0707-773b

Full Text - Reply to 'In vivo imaging of islet transplantation' | PDF (88 KB) - Reply to 'In vivo imaging of islet transplantation'

How alternative is alternative medicine? - p775

Bruno J Strasser reviews Mavericks of Medicine: Conversations on the Frontiers of Medicine by David Jay Brown

doi:10.1038/nm0707-775

Full Text - How alternative is alternative medicine? | PDF (76 KB) - How alternative is alternative medicine?

A new link to airway obstruction in asthma - pp777 - 778

David B Corry & Farrah Kheradmand

doi:10.1038/nm0707-777

Abstract - A new link to airway obstruction in asthma | Full Text - A new link to airway obstruction in asthma | PDF (428 KB) - A new link to airway obstruction in asthma

See also: Letter by Xiang et al.

IL-1 responds to necrotic cell death - pp778 - 780

Keith B Elkon

doi:10.1038/nm0707-778

Abstract - IL-1[alpha] responds to necrotic cell death | Full Text - IL-1 responds to necrotic cell death | PDF (432 KB) - IL-1 responds to necrotic cell death

See also: Letter by Chen et al.

Pulmonary barriers to pneumonia and sepsis - pp780 - 781

Michael A Matthay & Xiao Su

doi:10.1038/nm0707-780

Abstract - Pulmonary barriers to pneumonia and sepsis | Full Text - Pulmonary barriers to pneumonia and sepsis | PDF (677 KB) - Pulmonary barriers to pneumonia and sepsis

Stress, diet and abdominal obesity: Y? - pp781 - 783

James P Warne & Mary F Dallman

doi:10.1038/nm0707-781

Abstract - Stress, diet and abdominal obesity: Y? | Full Text - Stress, diet and abdominal obesity: Y? | PDF (1,061 KB) - Stress, diet and abdominal obesity: Y?

See also: Article by Kuo et al.

Turning skin into embryonic stem cells - pp783 - 784

Howard Y Chang & George Cotsarelis

doi:10.1038/nm0707-783

Abstract - Turning skin into embryonic stem cells | Full Text - Turning skin into embryonic stem cells | PDF (519 KB) - Turning skin into embryonic stem cells

Phosphoinositides' link to neurodegeneration - pp784 - 786

Laura Volpicelli-Daley & Pietro De Camilli

doi:10.1038/nm0707-784

Abstract - Phosphoinositides' link to neurodegeneration | Full Text - Phosphoinositides' link to neurodegeneration | PDF (774 KB) - Phosphoinositides' link to neurodegeneration

The problem with upward mobility - pp786 - 787

Johann E Gudjonsson & James T Elder

doi:10.1038/nm0707-786

Abstract - The problem with upward mobility | Full Text - The problem with upward mobility | PDF (2,626 KB) - The problem with upward mobility

See also: Article by Conrad et al.

Research highlights - p789

doi:10.1038/nm0707-789

Full Text - Research highlights | PDF (120 KB) - Research highlights

Skeletal remodeling in health and disease - pp791 - 801

Mone Zaidi

doi:10.1038/nm1593

Abstract - Skeletal remodeling in health and disease | Full Text - Skeletal remodeling in health and disease | PDF (6,569 KB) - Skeletal remodeling in health and disease

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome - pp803 - 811

Lydia E Kuo, Joanna B Kitlinska, Jason U Tilan, Lijun Li, Stephen B Baker, Michael D Johnson, Edward W Lee, Mary Susan Burnett, Stanley T Fricke, Richard Kvetnansky, Herbert Herzog & Zofia Zukowska

doi:10.1038/nm1611

Abstract - Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome | Full Text - Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome | PDF (576 KB) - Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome | Supplementary information

Fen1 mutations result in autoimmunity, chronic inflammation and cancers - pp812 - 819

Li Zheng, Huifang Dai, Mian Zhou, Mei Li, Purnima Singh, Junzhuan Qiu, Walter Tsark, Qin Huang, Kemp Kernstine, Xuemei Zhang, Dongxin Lin & Binghui Shen

doi:10.1038/nm1599

Abstract - Fen1: mutations result in autoimmunity, chronic inflammation and cancers | Full Text - Fen1 mutations result in autoimmunity, chronic inflammation and cancers | PDF (372 KB) - Fen1 mutations result in autoimmunity, chronic inflammation and cancers | Supplementary information

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC - pp820 - 827

Andrei Goga, Dun Yang, Aaron D Tward, David O Morgan & J Michael Bishop

doi:10.1038/nm1606

Abstract - Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC | Full Text - Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC | PDF (458 KB) - Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC | Supplementary information

Altered recognition of antigen is a mechanism of CD8⁺ T cell tolerance in cancer - pp828 - 835

Srinivas Nagaraj, Kapil Gupta, Vladimir Pisarev, Leo Kinarsky, Simon Sherman, Loveleen Kang, Donna L Herber, Jonathan Schneck & Dmitry I Gabrilovich

doi:10.1038/nm1609

Abstract - Altered recognition of antigen is a mechanism of CD8: +: T cell tolerance in cancer | Full Text - Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer | PDF (371 KB) - Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer | Supplementary information

₁₁ integrin is crucial for accumulation of epidermal T cells and the development of psoriasis - pp836 - 842

Curdin Conrad, Onur Boyman, Giulia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin de Fougerolles, Victor Kotelianski, Humphrey Gardner & Frank O Nestle

doi:10.1038/nm1605

Abstract - [alpha]: 1: [beta]: 1: integrin: is crucial for accumulation of epidermal T cells and the development of psoriasis | Full Text - 11 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis | PDF (500 KB) - 11 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis | Supplementary information

See also: News and Views by Gudjonsson & Elder

Multifunctional T_H1 cells define a correlate of vaccine-mediated protection against Leishmania major - pp843 - 850

Patricia A Darrah, Dipti T Patel, Paula M De Luca, Ross W B Lindsay, Dylan F Davey, Barbara J Flynn, Søren T Hoff, Peter Andersen, Steven G Reed, Sheldon L Morris, Mario Roederer & Robert A Seder

doi:10.1038/nm1592

Abstract - Multifunctional T: H: 1 cells define a correlate of vaccine-mediated protection against : Leishmania major | Full Text - Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major | PDF (495 KB) - Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major | Supplementary information

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells - pp851 - 856

Chun-Jen Chen, Hajime Kono, Douglas Golenbock, George Reed, Shizuo Akira & Kenneth L Rock

doi:10.1038/nm1603

First paragraph - Identification of a key pathway required for the sterile inflammatory response triggered by dying cells | Full Text - Identification of a key pathway required for the sterile inflammatory response triggered by dying cells | PDF (253 KB) - Identification of a key pathway required for the sterile inflammatory response triggered by dying cells | Supplementary information

See also: News and Views by Elkon

Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan - pp857 - 861

Jeffrey N Roberts, Christopher B Buck, Cynthia D Thompson, Rhonda Kines, Marcelino Bernardo, Peter L Choyke, Douglas R Lowy & John T Schiller

doi:10.1038/nm1598

First paragraph - Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan | Full Text - Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan | PDF (392 KB) - Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan | Supplementary information

A GABAergic system in airway epithelium is essential for mucus overproduction in asthma - pp862 - 867

Yun-Yan Xiang, Shuhe Wang, Mingyao Liu, Jeremy A Hirota, Jingxin Li, William Ju, Yijun Fan, Margaret M Kelly, Bin Ye, Beverley Orser, Paul M O'Byrne, Mark D Inman, Xi Yang & Wei-Yang Lu

doi:10.1038/nm1604

First paragraph - A GABAergic system in airway epithelium is essential for mucus overproduction in asthma | Full Text - A GABAergic system in airway epithelium is essential for mucus overproduction in asthma | PDF (621 KB) - A GABAergic system in airway epithelium is essential for mucus overproduction in asthma | Supplementary information

See also: News and Views by Corry & Kheradmand

Increased dietary intake of -3-polyunsaturated fatty acids reduces pathological retinal angiogenesis - pp868 - 873

Kip M Connor, John Paul SanGiovanni, Chatarina Lofqvist, Christopher M Aderman, Jing Chen, Akiko Higuchi, Song Hong, Elke A Pravda, Sharon Majchrzak, Deborah Carper, Ann Hellstrom, Jing X Kang, Emily Y Chew, Norman Salem, Jr, Charles N Serhan & Lois E H Smith

doi:10.1038/nm1591

First paragraph - Increased dietary intake of [omega]-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis | Full Text - Increased dietary intake of -3-polyunsaturated fatty acids reduces pathological retinal angiogenesis | PDF (410 KB) - Increased dietary intake of -3-polyunsaturated fatty acids reduces pathological retinal angiogenesis | Supplementary information

Real-time measurement of free Ca²⁺ changes in CNS myelin by two-photon microscopy - pp874 - 879

Ileana Micu, Andrew Ridsdale, Lingqing Zhang, John Woulfe, Jeff McClintock, Christine A Brantner, S Brian Andrews & Peter K Stys

doi:10.1038/nm1568

Abstract - Real-time measurement of free Ca: 2+: changes in CNS myelin by two-photon microscopy | Full Text - Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy | PDF (405 KB) - Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy | Supplementary information

Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets - pp880 - 885

Kazuo Ohashi, Takashi Yokoyama, Masayuki Yamato, Hiroyuki Kuge, Hiromichi Kanehiro, Masahiro Tsutsumi, Toshihiro Amanuma, Hiroo Iwata, Joseph Yang, Teruo Okano & Yoshiyuki Nakajima

doi:10.1038/nm1576

Abstract - Engineering functional two- and three-dimensional liver systems : in vivo: using hepatic tissue sheets | Full Text - Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets | PDF (350 KB) - Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets | Supplementary information