Access

News and Views


Nature Medicine 13, 784 - 786 (2007)
doi:10.1038/nm0707-784

Phosphoinositides' link to neurodegeneration

Laura Volpicelli-Daley1 & Pietro De Camilli1

  1. Laura Volpicelli-Daley and Pietro De Camilli are in the Department of Cell Biology, Howard Hughes Medical Institute and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA. e-mail: pietro.decamilli@yale.edu


Mutations in the phosphoinositide metabolism gene FIG4 disrupt the endosomal pathway, leading to neurodegeneration and a newly identified variant of Charcot-Marie-Tooth disorder.


Phosphorylated metabolites of phosphatidylinositol, the phosphoinositides, have long been known to play an important role in signal transduction at the cell surface. More recently, they have emerged as important regulators of the membrane-cytosol interface on a variety of intracellular organelles1, 2.

$rb.Type.Code