1. David B. Corry and Farrah Kheradmand are in the Departments of Medicine and Immunology, Baylor College of Medicine, One Baylor Plaza, BCM285, Houston, Texas 77030, USA. e-mail: dcorry@bcm.tmc.edu

Abstract

The factors that regulate airway goblet cell metaplasia and mucus secretion are essential to understanding how airway obstruction occurs in asthma. In this issue, Xiang et al. demonstrate the existence of an airway epithelial, extraneuronal GABAergic signaling system that promotes mucus overproduction during allergic airway inflammation (pages 862–867).

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