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Nature Medicine 13, 742-747 (1 June 2007) | doi:10.1038/nm1578;
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
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Abstract
Cell-intrinsic checkpoints limit the proliferative capacity of primary cells in response to telomere dysfunction. It is not known, however, whether telomere dysfunction contributes to cell-extrinsic alterations that impair stem cell function and organ homeostasis.
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