Access
To read this story in full you will need to login or make a payment (see right).
Brief Communication
Nature Medicine 13, 685 - 687 (2007)
Published online: 21 May 2007 | doi:10.1038/nm1596
Restoration of cone vision in a mouse model of achromatopsia
John J Alexander1, Yumiko Umino2, Drew Everhart2, Bo Chang3, Seok H Min4, Qiuhong Li4, Adrian M Timmers4,5, Norman L Hawes3, Ji-jing Pang4, Robert B Barlow2 & William W Hauswirth1,4
Abstract
Loss of cone function in the central retina is a pivotal event in the development of severe vision impairment for many prevalent blinding diseases. Complete achromatopsia is a genetic defect resulting in cone vision loss in 1 in 30,000 individuals. Using adeno-associated virus (AAV) gene therapy, we show that it is possible to target cones and rescue both the cone-mediated electroretinogram response and visual acuity in the Gnat2 cpfl3 mouse model of achromatopsia.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Unraveling the ribbon synapseNature Neuroscience News and Views (01 Aug 2008)
The sights along route 65Nature Genetics News and Views (01 Sep 2001)
RESEARCH
Restoration of cone vision in a mouse model of achromatopsiaNature Medicine Brief Communication
Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood BlindnessMolecular Therapy Original Article
See all 73 matches for Research