Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 671 - 673 (2007)
doi:10.1038/nm0607-671
Retinaldehyde: more than meets the eye
Béatrice Desvergne1
- Béatrice Desvergne is at the University of Lausanne, Center of Integrative Genomics, Lausanne, Switzerland. e-mail: beatrice.desvergne@unil.ch
Abstract
Retinaldehyde, an intermediate metabolite between vitamin A and retinoic acid, is present at biologically active concentrations in fat tissue, where it antagonizes PPAR-
activity, inhibiting adipogenesis and improving insulin sensitivity.
The identification of nuclear receptors defined a new paradigm: small lipophilic hormones specifically bind their cognate receptor and the complex directly regulates the expression of multiple targets. The genes controlled by these activated nuclear receptor transcription factors are diverse, and they act on energy balance, lipid metabolism and glucose homeostasis, to name a few.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Retinoid metabolism: a balancing actNature Genetics News and Views (01 May 2002)
Metabolism A is for adipokineNature News and Views (21 Jul 2005)
See all 3 matches for News And ViewsRESEARCH
Interaction of tau protein with the dynactin complexThe EMBO Journal Article (31 Oct 2007)
Retinaldehyde represses adipogenesis and diet-induced obesityNature Medicine Article (01 Jun 2007)
See all 26 matches for Research