1. Carlos L. Arteaga is in the Departments of Medicine and Cancer Biology and the Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center; Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. e-mail: carlos.arteaga@vanderbilt.edu

Abstract

Non-small-cell lung cancers with activating mutations in the epidermal growth factor receptor develop resistance to tyrosine kinase inhibitors by recruiting the MET receptor kinase to activate HER3 and the PI3K-Akt cell survival pathway.

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