1. Béatrice Desvergne is at the University of Lausanne, Center of Integrative Genomics, Lausanne, Switzerland. e-mail: beatrice.desvergne@unil.ch

Abstract

Retinaldehyde, an intermediate metabolite between vitamin A and retinoic acid, is present at biologically active concentrations in fat tissue, where it antagonizes PPAR- activity, inhibiting adipogenesis and improving insulin sensitivity.

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