News and Views
Nature Medicine 13, 669 - 671 (2007)
doi:10.1038/nm0607-669
Linking calcineurin activity to leukemogenesis
Martin R Müller1 & Anjana Rao1
- The authors are in the Department of Pathology, Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA. e-mail: arao@cbr.med.harvard.edu
Abstract
Aberrant activation of the protein phosphatase calcineurin is found in various cancer types. Inhibition of calcineurin leads to a rapid clearance of leukemic cells and significantly improves animal survival in two mouse models of acute T lymphoblastic leukemia.
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