News and Views
Nature Medicine 13, 667 - 669 (2007)
doi:10.1038/nm0607-667
Heme moves to center stage in cerebral malaria
Nicholas H Hunt1 & Roland Stocker1
- Nicholas H. Hunt is at the Molecular Immunopathology Unit and Roland Stocker is at the Centre for Vascular Research; Bosch Institute and Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia. e-mail: nicholas.hunt@bosch.org.au
Abstract
In a mouse model of cerebral malaria, free heme molecules can induce inflammation and permeabilization of the blood brain barrier, leading to death. The enzyme heme oxygenase-1 or its product carbon monoxide can decrease free heme levels, offering a new therapeutic approach to this deadly complication.
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