Minority report - p513

doi:10.1038/nm0507-513

Abstract - Minority report | Full Text - Minority report | PDF (95 KB) - Minority report

Scientists, NIH in conflict over precious HIV samples - p515

Apoorva Mandavilli

doi:10.1038/nm0507-515

Abstract - Scientists, NIH in conflict over precious HIV samples | Full Text - Scientists, NIH in conflict over precious HIV samples | PDF (161 KB) - Scientists, NIH in conflict over precious HIV samples

Criticism swells against AIDS program's abstinence policy - p516

Erika Check

doi:10.1038/nm0507-516a

Abstract - Criticism swells against AIDS program's abstinence policy | Full Text - Criticism swells against AIDS program's abstinence policy | PDF (355 KB) - Criticism swells against AIDS program's abstinence policy

Epilepsy controlled by low-carb diet's effect on brain channels - pp516 - 517

Emily Waltz

doi:10.1038/nm0507-516b

Abstract - Epilepsy controlled by low-carb diet's effect on brain channels | Full Text - Epilepsy controlled by low-carb diet's effect on brain channels | PDF (392 KB) - Epilepsy controlled by low-carb diet's effect on brain channels

Dramatic rescue relieves rare case of smallpox infection - p517

Emma Marris

doi:10.1038/nm0507-517

Abstract - Dramatic rescue relieves rare case of smallpox infection | Full Text - Dramatic rescue relieves rare case of smallpox infection | PDF (98 KB) - Dramatic rescue relieves rare case of smallpox infection

Will there be an HIV vaccine in the next 10 years? - pp518 - 519

doi:10.1038/nm0507-518b

Abstract - Will there be an HIV vaccine in the next 10 years? | Full Text - Will there be an HIV vaccine in the next 10 years? | PDF (449 KB) - Will there be an HIV vaccine in the next 10 years?

High-profile departure ends genome institute's charmed run - p518

Meredith Wadman

doi:10.1038/nm1594

Full Text - High-profile departure ends genome institute's charmed run | PDF (281 KB) - High-profile departure ends genome institute's charmed run

US tosses out patents on three Wisconsin stem cell lines - p519

Alisa Opar

doi:10.1038/nm0507-519

Abstract - US tosses out patents on three Wisconsin stem cell lines | Full Text - US tosses out patents on three Wisconsin stem cell lines | PDF (228 KB) - US tosses out patents on three Wisconsin stem cell lines

News in brief - pp520 - 521

doi:10.1038/nm0507-520

Full Text - News in brief | PDF (788 KB) - News in brief

News feature: Bugs vs Drugs - pp522 - 523

Douglas Braaten

doi:10.1038/nm0507-522

Abstract - News feature: Bugs vs Drugs | Full Text - News feature: Bugs vs Drugs | PDF (400 KB) - News feature: Bugs vs Drugs

Straight talk from... Jim Young - p524

Apoorva Mandavilli

doi:10.1038/nm0507-524

Abstract - Straight talk from... Jim Young | Full Text - Straight talk from... Jim Young | PDF (115 KB) - Straight talk from... Jim Young

Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans' - pp525 - 526

Mehdi Tafti

doi:10.1038/nm0507-525

Full Text - Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans' | PDF (82 KB) - Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans'

Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans' - p526

Francois Jenck, Catherine Brisbare-Roch, Michael Scherz, Susan Flores, Ralf Koberstein, Oliver Nayler, Jasper Dingemanse & Martine Clozel

doi:10.1038/nm0507-526

Full Text - Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans' | PDF (73 KB) - Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans'

The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells - pp527 - 528

Takeo Ohsugi, Toshio Kumasaka, Seiji Okada & Toru Urano

doi:10.1038/nm0507-527

Full Text - The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells | PDF (267 KB) - The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells

Getting under the skin - p529

Ian J Jackson reviews Skin: A Natural History

doi:10.1038/nm0507-529

Full Text - Getting under the skin | PDF (65 KB) - Getting under the skin

Flushing bacteria out of the bladder - pp531 - 532

Danelle S Eto & Matthew A Mulvey

doi:10.1038/nm0507-531

Abstract - Flushing bacteria out of the bladder | Full Text - Flushing bacteria out of the bladder | PDF (395 KB) - Flushing bacteria out of the bladder

See also: Letter by Bishop et al.

The popcorn plaques - pp532 - 534

Jagat Narula & H William Strauss

doi:10.1038/nm0507-532

Abstract - The popcorn plaques | Full Text - The popcorn plaques | PDF (275 KB) - The popcorn plaques

See also: Technical Report by Hyafil et al.

Autism: highly heritable but not inherited - pp534 - 536

Arthur L Beaudet

doi:10.1038/nm0507-534

Abstract - Autism: highly heritable but not inherited | Full Text - Autism: highly heritable but not inherited | PDF (145 KB) - Autism: highly heritable but not inherited

The bridge between dendritic cells and asthma - pp536 - 538

Mari L Shinohara & Harvey Cantor

doi:10.1038/nm0507-536

Abstract - The bridge between dendritic cells and asthma | Full Text - The bridge between dendritic cells and asthma | PDF (379 KB) - The bridge between dendritic cells and asthma

See also: Article by Xanthou et al.

A new way to regulate the NMJ - pp538 - 539

Kay E Davies & Tejvir S Khurana

doi:10.1038/nm0507-538

Abstract - A new way to regulate the NMJ | Full Text - A new way to regulate the NMJ | PDF (220 KB) - A new way to regulate the NMJ

Eat your heart out - pp539 - 541

Richard N Kitsis, Chang-Fu Peng & Ana Maria Cuervo

doi:10.1038/nm0507-539

Abstract - Eat your heart out | Full Text - Eat your heart out | PDF (225 KB) - Eat your heart out

See also: Letter by Nakai et al.

MicroRNAs loom large in the heart - p541

Michael Basson

doi:10.1038/nm0507-541

Full Text - MicroRNAs loom large in the heart | PDF (97 KB) - MicroRNAs loom large in the heart

Research highlights - p542

doi:10.1038/nm0507-542

Full Text - Research highlights | PDF (107 KB) - Research highlights

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity - pp543 - 551

Roberto Baccala, Kasper Hoebe, Dwight H Kono, Bruce Beutler & Argyrios N Theofilopoulos

doi:10.1038/nm1590

Abstract - TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity | Full Text - TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity | PDF (1,734 KB) - TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists - pp552 - 559

Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman

doi:10.1038/nm1589

Abstract - Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists | Full Text - Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists | PDF (1,323 KB) - Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? - pp561 - 566

Grégoire Courtine, Mary Bartlett Bunge, James W Fawcett, Robert G Grossman, Jon H Kaas, Roger Lemon, Irin Maier, John Martin, Randolph J Nudo, Almudena Ramon-Cueto, Eric M Rouiller, Lisa Schnell, Thierry Wannier, Martin E Schwab & V Reggie Edgerton

doi:10.1038/nm1595

Full Text - Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? | PDF (378 KB) - Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

Antielastin autoimmunity in tobacco smoking–induced emphysema - pp567 - 569

Seung-Hyo Lee, Sangeeta Goswami, Ariel Grudo, Li-zhen Song, Venkata Bandi, Sheila Goodnight-White, Linda Green, Joan Hacken-Bitar, Joseph Huh, Faisal Bakaeen, Harvey O Coxson, Sebastian Cogswell, Claudine Storness-Bliss, David B Corry & Farrah Kheradmand

doi:10.1038/nm1583

Abstract - Antielastin autoimmunity in tobacco smoking-induced emphysema | Full Text - Antielastin autoimmunity in tobacco smoking–induced emphysema | PDF (271 KB) - Antielastin autoimmunity in tobacco smoking–induced emphysema | Supplementary information

Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets - pp570 - 578

Georgina Xanthou, Themis Alissafi, Maria Semitekolou, Davina C M Simoes, Erasmia Economidou, Mina Gaga, Bart N Lambrecht, Clare M Lloyd & Vily Panoutsakopoulou

doi:10.1038/nm1580

Abstract - Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets | Full Text - Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets | PDF (583 KB) - Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

See also: News and Views by Shinohara & Cantor

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy - pp579 - 586

Ursula Grohmann, Claudia Volpi, Francesca Fallarino, Silvia Bozza, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Emira Ayroldi, Giuseppe Nocentini, Louis Boon, Francesco Bistoni, Maria C Fioretti, Luigina Romani, Carlo Riccardi & Paolo Puccetti

doi:10.1038/nm1563

Abstract - Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy | Full Text - Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy | PDF (444 KB) - Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy | Supplementary information

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment - pp587 - 596

Jürgen Bernhagen, Regina Krohn, Hongqi Lue, Julia L Gregory, Alma Zernecke, Rory R Koenen, Manfred Dewor, Ivan Georgiev, Andreas Schober, Lin Leng, Teake Kooistra, Günter Fingerle-Rowson, Pietro Ghezzi, Robert Kleemann, Shaun R McColl, Richard Bucala, Michael J Hickey & Christian Weber

doi:10.1038/nm1567

Abstract - MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment | Full Text - MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment | PDF (445 KB) - MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment | Supplementary information

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes - pp597 - 603

Rebecca Berdeaux, Naomi Goebel, Laura Banaszynski, Hiroshi Takemori, Thomas Wandless, G Diane Shelton & Marc Montminy

doi:10.1038/nm1573

Abstract - SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes | Full Text - SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes | PDF (440 KB) - SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes | Supplementary information

Sema3a maintains normal heart rhythm through sympathetic innervation patterning - pp604 - 612

Masaki Ieda, Hideaki Kanazawa, Kensuke Kimura, Fumiyuki Hattori, Yasuyo Ieda, Masahiko Taniguchi, Jong-Kook Lee, Keisuke Matsumura, Yuichi Tomita, Shunichiro Miyoshi, Kouji Shimoda, Shinji Makino, Motoaki Sano, Itsuo Kodama, Satoshi Ogawa & Keiichi Fukuda

doi:10.1038/nm1570

Abstract - Sema3a maintains normal heart rhythm through sympathetic innervation patterning | Full Text - Sema3a maintains normal heart rhythm through sympathetic innervation patterning | PDF (1,056 KB) - Sema3a maintains normal heart rhythm through sympathetic innervation patterning | Supplementary information

MicroRNA-133 controls cardiac hypertrophy - pp613 - 618

Alessandra Carè, Daniele Catalucci, Federica Felicetti, Désirée Bonci, Antonio Addario, Paolo Gallo, Marie-Louise Bang, Patrizia Segnalini, Yusu Gu, Nancy D Dalton, Leonardo Elia, Michael V G Latronico, Morten Høydal, Camillo Autore, Matteo A Russo, Gerald W Dorn, II, Øyvind Ellingsen, Pilar Ruiz-Lozano, Kirk L Peterson, Carlo M Croce, Cesare Peschle & Gianluigi Condorelli

doi:10.1038/nm1582

First paragraph - MicroRNA-133: controls cardiac hypertrophy | Full Text - MicroRNA-133 controls cardiac hypertrophy | PDF (242 KB) - MicroRNA-133 controls cardiac hypertrophy | Supplementary information

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress - pp619 - 624

Atsuko Nakai, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shungo Hikoso, Masayuki Taniike, Shigemiki Omiya, Isamu Mizote, Yasushi Matsumura, Michio Asahi, Kazuhiko Nishida, Masatsugu Hori, Noboru Mizushima & Kinya Otsu

doi:10.1038/nm1574

First paragraph - The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress | Full Text - The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress | PDF (426 KB) - The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress | Supplementary information

See also: News and Views by Kitsis et al.

Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells - pp625 - 630

Brian L Bishop, Mathew J Duncan, Jeongmin Song, Guojie Li, David Zaas & Soman N Abraham

doi:10.1038/nm1572

First paragraph - Cyclic AMP-regulated exocytosis of : Escherichia coli: from infected bladder epithelial cells | Full Text - Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells | PDF (355 KB) - Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells | Supplementary information

See also: News and Views by Eto & Mulvey

Rhesus monkey TRIM5 restricts HIV-1 production through rapid degradation of viral Gag polyproteins - pp631 - 635

Ryuta Sakuma, Josh A Noser, Seiga Ohmine & Yasuhiro Ikeda

doi:10.1038/nm1562

First paragraph - Rhesus monkey TRIM5[alpha] restricts HIV-1 production through rapid degradation of viral Gag polyproteins | Full Text - Rhesus monkey TRIM5 restricts HIV-1 production through rapid degradation of viral Gag polyproteins | PDF (221 KB) - Rhesus monkey TRIM5 restricts HIV-1 production through rapid degradation of viral Gag polyproteins | Supplementary information

Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography - pp636 - 641

Fabien Hyafil, Jean-Christophe Cornily, Jonathan E Feig, Ronald Gordon, Esad Vucic, Vardan Amirbekian, Edward A Fisher, Valentin Fuster, Laurent J Feldman & Zahi A Fayad

doi:10.1038/nm1571

Abstract - Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography | Full Text - Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography | PDF (464 KB) - Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography | Supplementary information

See also: News and Views by Narula & Strauss

Derivation of engraftable skeletal myoblasts from human embryonic stem cells - pp642 - 648

Tiziano Barberi, Michelle Bradbury, Zehra Dincer, Georgia Panagiotakos, Nicholas D Socci & Lorenz Studer

doi:10.1038/nm1533

Abstract - Derivation of engraftable skeletal myoblasts from human embryonic stem cells | Full Text - Derivation of engraftable skeletal myoblasts from human embryonic stem cells | PDF (477 KB) - Derivation of engraftable skeletal myoblasts from human embryonic stem cells | Supplementary information