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Nature Medicine 13, 531 - 532 (2007)
doi:10.1038/nm0507-531
Flushing bacteria out of the bladder
Danelle S Eto1 & Matthew A Mulvey1
- The authors are in the Division of Cell Biology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah 84112, USA. e-mail: mulvey@path.utah.edu
Abstract
A drug that elevates host cAMP levels forces pathogenic bacteria out of bladder epithelial cells. This process may make urinary tract infections more amenable to treatment with antibiotics (pages 625–630).
With over one hundred million infections annually, urinary tract infections (UTIs) remain among the most common infectious diseases worldwide, despite improved hygiene and widespread antibiotic use1. Even with antibiotic treatment, UTIs can linger and recur in many individuals, such that 25% of women have recurrent symptoms within six months of an initial acute infection2.
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RESEARCH
Cyclic AMP?regulated exocytosis of Escherichia coli from infected bladder epithelial cellsNature Medicine Letter (01 May 2007)
Cyclic AMP?regulated exocytosis of Escherichia coli from infected bladder epithelial cellsNature Medicine Letter (01 May 2007)
Cyclic AMP?regulated exocytosis of Escherichia coli from infected bladder epithelial cellsNature Medicine Letter
